Piperazin-2-one → ([5-(3-Chloro-5-fluorophenyl)-1-(5-chloropyridin-3-yl)-1H-pyrazol-3-yl]carbonyl}piperazin-2-one

HRID 930053Notes

Reaction equation

HRID 930053 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([Cl:20])[CH:19]=3)[N:12]=[C:11]([C:21]([OH:23])=O)[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C([C:43]([N:45]3[CH2:49][C:48](=[O:50])[NH:47][CH2:46]3)=O)C=2)C=C(F)C=1.O=C1CNCCN1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([Cl:20])[CH:19]=3)[N:12]=[C:11]([C:21]([N:47]3[CH2:46][CH2:43][NH:45][CH2:49][C:48]3=[O:50])=[O:23])[CH:10]=2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

4

Reactant 3

HCID 231360Piperazin-2-oneHCID 71576484HCID 71576484, compoundHCID 89609998HCID 89609998, compound

Product 1

HCID 131735145([5-(3-Chloro-5-fluorophenyl)-1-(5-chloropyridin-3-yl)-1H-pyrazol-3-yl]carbonyl}piperazin-2-one

Procedure

75 mg (0.21 mmol) of the compound of Example 26A is reacted analogously to the synthesis of the compound of Example 1 with 23 mg (0.23 mmol) of 2-oxopiperazine. 77 mg (83% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-15b2ba772abf4667a62a5ee95a809285
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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