HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → ([5-(3-Chloro-5-fluorophenyl)-1-(5-chloropyridin-3-yl)-1H-pyrazol-3-yl]carbonyl}piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | HCID 71576484 | HCID 71576484 | — |
| Reactant | HCID 89609998 | HCID 89609998 | — |
| Product | ([5-(3-Chloro-5-fluorophenyl)-1-(5-chloropyridin-3-yl)-1H-pyrazol-3-yl]carbonyl}piperazin-2-one | HCID 131735145 | — |
Reaction Steps
75 mg (0.21 mmol) of the compound of Example 26A is reacted analogously to the synthesis of the compound of Example 1 with 23 mg (0.23 mmol) of 2-oxopiperazine. 77 mg (83% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-15b2ba772abf4667a62a5ee95a809285 |
| Source note | uspto-grants-2016_03 |