Thiazolidine → [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-fluoro-3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone

HRID 930070Notes

Reaction equation

HRID 930070 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][C:21]([F:24])=[CH:22][CH:23]=3)[N:16]=[C:15]([C:25]([OH:27])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(N3CC(=O)NC3)=O)C=2)C=C(F)C=1.[S:55]1[CH2:59][CH2:58][NH:57][CH2:56]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][C:21]([F:24])=[CH:22][CH:23]=3)[N:16]=[C:15]([C:25]([N:57]3[CH2:58][CH2:59][S:55][CH2:56]3)=[O:27])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:10])[F:11])[CH:7]=1

Participants

4

Reactant 3

HCID 10444ThiazolidineHCID 71576484HCID 71576484, compoundHCID 89609969HCID 89609969, compound

Product 1

HCID 86574607[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(6-fluoro-3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone

Procedure

113 mg (0.25 mmol) of the compound of Example 42A is reacted analogously to the synthesis of the compound of Example 1 with 25 mg (0.28 mmol) of thiazolidine. 91 mg (70% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-4c38bbbf12b749c2b51ba605e0f279c8
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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