HCID 66687731, compound → 1-[5-[3-Fluoro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

HRID 930082Notes

Reaction equation

HRID 930082 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([OH:26])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:48]3[CH2:52][C:51](=[O:53])[NH:50][CH2:49]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([N:48]3[CH2:52][C:51](=[O:53])[NH:50][CH2:49]3)=[O:26])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:10])([F:12])[F:11])[CH:7]=1

Participants

4

Reactant 3

HCID 66687731HCID 66687731, compoundHCID 71576484HCID 71576484, compoundHCID 896025085-(3-Fluoro-5-trifluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 865746551-[5-[3-Fluoro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazole-3-carbonyl]imidazolidin-4-one

Procedure

100 mg (0.27 mmol) of the compound of Example 34A is reacted analogously to the synthesis of the compound of Example 1 with 37 mg (0.30 mmol) of 4-imidazolinone-hydrochloride. 98 mg (83% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-059b47663abb4e44be67c07cb3084d47
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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