反应详情

102 mg (0.23 mmol) of the compound of Example 59 is dissolved in 5 ml of dichloromethane, mixed with 57 mg (0.23 mmol, 70% purity) of meta-chloroperbenzoic acid, and stirred for 16 hours at room temperature. The reaction mixture is concentrated by evaporation in a rotary evaporator, mixed with some acetonitrile, filtered over a Millipore spray filter, and then separated by means of preparative HPLC (mobile solvent: acetonitrile/water gradient). 87 mg (82% of theory) of the title compound is obtained.

1. concentrationThe reaction mixture is concentrated by evaporation in a rotary evaporator
2. additionmixed with some acetonitrile
3. filtrationfiltered over a Millipore spray
4. filtrationfilter
5. customseparated by means of preparative HPLC (mobile solvent: acetonitrile/water gradient)