Morpholine → [5-[3-Fluoro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-morpholino-methanone

HRID 930085Notes

Reaction equation

HRID 930085 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24](O)=[O:25])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=[C:37]([C:46]([N:48]3[CH2:52][C:51](=[O:53])NC3)=O)C=2)C=C(F)C=1.N1CCOCC1>>[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([N:48]3[CH2:46][CH2:37][O:53][CH2:51][CH2:52]3)=[O:25])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:10])[F:11])[CH:7]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 71576484HCID 71576484, compoundHCID 896025085-(3-Fluoro-5-trifluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 86574669[5-[3-Fluoro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-morpholino-methanone

Procedure

75 mg (0.20 mmol) of the compound of Example 34A is reacted analogously to the synthesis of the compound of Example 1 with 0.02 ml (0.23 mmol) of morpholine. 80 mg (90% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-2fbae958397e41868621366312f042d5
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

Loading…