Thiazolidine → [5-[3-Chloro-5-(difluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone

HRID 930091Notes

Reaction equation

HRID 930091 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[N:16]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[N:15]=[C:14]([C:23](O)=[O:24])[CH:13]=2)[CH:5]=[C:6]([O:8][CH:9]([F:11])[F:10])[CH:7]=1.[S:26]1[CH2:30][CH2:29][NH:28][CH2:27]1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:12]2[N:16]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[N:15]=[C:14]([C:23]([N:28]3[CH2:29][CH2:30][S:26][CH2:27]3)=[O:24])[CH:13]=2)[CH:5]=[C:6]([O:8][CH:9]([F:10])[F:11])[CH:7]=1

Participants

3

Reactant 2

HCID 10444ThiazolidineHCID 896024835-(3-Chloro-5-difluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 86574541[5-[3-Chloro-5-(difluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone

Procedure

95 mg (0.26 mmol) of the compound of Example 54A is reacted analogously to the synthesis of the compound of Example 3 with 25 mg (0.28 mmol) of thiazolidine for 30 minutes at room temperature. 65 mg (57% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-3f3b8c72ed9b46dc9b260f0f3aa64cf4
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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