HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazolidine → [5-[3-Chloro-5-(difluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazolidine | HCID 10444 | — |
| Reactant | 5-(3-Chloro-5-difluoromethoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid | HCID 89602483 | — |
| Product | [5-[3-Chloro-5-(difluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone | HCID 86574541 | — |
Reaction Steps
95 mg (0.26 mmol) of the compound of Example 54A is reacted analogously to the synthesis of the compound of Example 3 with 25 mg (0.28 mmol) of thiazolidine for 30 minutes at room temperature. 65 mg (57% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-3f3b8c72ed9b46dc9b260f0f3aa64cf4 |
| Source note | uspto-grants-2016_03 |