Piperazin-2-one → ([5-(3-Bromo-5-methoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazol-3-yl]carbonyl}piperazin-2-one

HRID 930099Notes

Reaction equation

HRID 930099 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[N:14]([C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)[N:13]=[C:12]([C:21](O)=[O:22])[CH:11]=2)[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C([C:43]([N:45]3[CH2:49][C:48](=[O:50])[NH:47][CH2:46]3)=O)C=2)C=C(F)C=1.O=C1CNCCN1>>[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[N:14]([C:15]3[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=3)[N:13]=[C:12]([C:21]([N:47]3[CH2:46][CH2:43][NH:45][CH2:49][C:48]3=[O:50])=[O:22])[CH:11]=2)[CH:5]=[C:6]([O:8][CH3:9])[CH:7]=1

Participants

4

Reactant 3

HCID 231360Piperazin-2-oneHCID 71576484HCID 71576484, compoundHCID 896025285-(3-Bromo-5-methoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 131735146([5-(3-Bromo-5-methoxyphenyl)-1-(pyridin-3-yl)-1H-pyrazol-3-yl]carbonyl}piperazin-2-one

Procedure

50 mg (0.13 mmol) of the compound of Example 50A is reacted analogously to the synthesis of the compound of Example 1 with 15 mg (0.15 mmol) of 2-oxopiperazine. 54 mg (88% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-28b37db8596c4644bd135932ff9371a4
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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