HCID 66687731, compound → 1-[1-(3-Chloro-4-fluoro-phenyl)-5-[5-(difluoromethoxy)-3-pyridyl]pyrazole-3-carbonyl]imidazolidin-4-one

HRID 930109Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([O:20][CH:21]([F:23])[F:22])[CH:19]=3)=[CH:12][C:11]([C:24](O)=[O:25])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(C2N(C3C=CC=CN=3)N=C(C([N:48]3[CH2:52][C:51](=[O:53])[NH:50][CH2:49]3)=O)C=2)C=C(F)C=1.Cl.N1C=CNC1=O>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:15]=[N:16][CH:17]=[C:18]([O:20][CH:21]([F:22])[F:23])[CH:19]=3)=[CH:12][C:11]([C:24]([N:48]3[CH2:52][C:51](=[O:53])[NH:50][CH2:49]3)=[O:25])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 3

HCID 66687731HCID 66687731, compound

HCID 71576484HCID 71576484, compound

HCID 896099601-(3-Chloro-4-fluorophenyl)-5-(5-difluoromethoxypyridin-3-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 865743091-[1-(3-Chloro-4-fluoro-phenyl)-5-[5-(difluoromethoxy)-3-pyridyl]pyrazole-3-carbonyl]imidazolidin-4-one

Procedure

109 mg (0.28 mmol) of the compound of Example 65A is reacted analogously to the synthesis of the compound of Example 1 with 38 mg (0.31 mmol) of 4-imidazolinone-hydrochloride. 108 mg (84% of theory) of the title compound is obtained.

Sources & evidence

ORD record: ord-bdb65d6d7adf432e87a000aa2d566bff
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296720B2

Reaction notes

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