HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 66687731, compound → 1-[1-(3-Chloro-4-fluoro-phenyl)-5-[5-(difluoromethoxy)-3-pyridyl]pyrazole-3-carbonyl]imidazolidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 66687731 | HCID 66687731 | — |
| Reactant | HCID 71576484 | HCID 71576484 | — |
| Reactant | 1-(3-Chloro-4-fluorophenyl)-5-(5-difluoromethoxypyridin-3-yl)-1H-pyrazole-3-carboxylic acid | HCID 89609960 | — |
| Product | 1-[1-(3-Chloro-4-fluoro-phenyl)-5-[5-(difluoromethoxy)-3-pyridyl]pyrazole-3-carbonyl]imidazolidin-4-one | HCID 86574309 | — |
Reaction Steps
109 mg (0.28 mmol) of the compound of Example 65A is reacted analogously to the synthesis of the compound of Example 1 with 38 mg (0.31 mmol) of 4-imidazolinone-hydrochloride. 108 mg (84% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-bdb65d6d7adf432e87a000aa2d566bff |
| Source note | uspto-grants-2016_03 |