HRID930114

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID231360

Piperazin-2-one

C4H8N2O

结构：O=C1CN(C(=O)c2cc(-c3cc(F)cc(Cl)c3)n(-c3ccccn3)n2)CN1

HCID71576484

未命名化合物

结构：O=C(O)c1cc(-c2cc(Br)cc(OC(F)(F)F)c2)n(-c2ccnc(C(F)(F)F)c2)n1

HCID89610054

未命名化合物

PRODUCTS

生成物

结构：O=C1CN(C(=O)c2cc(-c3cc(Br)cc(OC(F)(F)F)c3)n(-c3ccnc(C(F)(F)F)c3)n2)CCN1

HCID86574675

未命名化合物

PROCEDURE

实验过程

75 mg (0.15 mmol) of the compound of Example 47A is reacted analogously to the synthesis of the compound of Example 1 with 17 mg (0.17 mmol) of 2-oxopiperazine. 74 mg (84% of theory) of the title compound is obtained.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6f1cd52c14234fd3b3675a18af36defb
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09296720B2
来源说明: uspto-grants-2016_03

反应 SMILES

[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=3)[N:16]=[C:15]([C:28]([OH:30])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C([C:50]([N:52]3[CH2:56][C:55](=[O:57])[NH:54][CH2:53]3)=O)C=2)C=C(F)C=1.O=C1CNCCN1>>[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([C:24]([F:27])([F:25])[F:26])[CH:19]=3)[N:16]=[C:15]([C:28]([N:52]3[CH2:50][CH2:53][NH:54][C:55](=[O:57])[CH2:56]3)=[O:30])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:11])([F:10])[F:12])[CH:7]=1