HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 4-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-[2-(trifluoromethyl)-4-pyridyl]pyrazole-3-carbonyl]piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | HCID 71576484 | HCID 71576484 | — |
| Reactant | 5-(3-Bromo-5-trifluoromethoxyphenyl)-1-(2-trifluoromethylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89610054 | — |
| Product | 4-[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-[2-(trifluoromethyl)-4-pyridyl]pyrazole-3-carbonyl]piperazin-2-one | HCID 86574675 | — |
Reaction Steps
75 mg (0.15 mmol) of the compound of Example 47A is reacted analogously to the synthesis of the compound of Example 1 with 17 mg (0.17 mmol) of 2-oxopiperazine. 74 mg (84% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-6f1cd52c14234fd3b3675a18af36defb |
| Source note | uspto-grants-2016_03 |