Thiazolidine → [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-[2-(trifluoromethyl)-4-pyridyl]pyrazol-3-yl]-thiazolidin-3-yl-methanone

HRID 930115Notes

Reaction equation

HRID 930115 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=3)[N:16]=[C:15]([C:28]([OH:30])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(N3CC(=O)NC3)=O)C=2)C=C(F)C=1.[S:58]1[CH2:62][CH2:61][NH:60][CH2:59]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:23]=[CH:22][N:21]=[C:20]([C:24]([F:26])([F:25])[F:27])[CH:19]=3)[N:16]=[C:15]([C:28]([N:60]3[CH2:61][CH2:62][S:58][CH2:59]3)=[O:30])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:11])([F:10])[F:12])[CH:7]=1

Participants

4

Reactant 3

HCID 10444ThiazolidineHCID 71576484HCID 71576484, compoundHCID 896100545-(3-Bromo-5-trifluoromethoxyphenyl)-1-(2-trifluoromethylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 86574676[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-[2-(trifluoromethyl)-4-pyridyl]pyrazol-3-yl]-thiazolidin-3-yl-methanone

Procedure

130 mg (0.26 mmol) of the compound of Example 47A is reacted analogously to the synthesis of the compound of Example 1 with 26 mg (0.29 mmol) of thiazolidine. 105 mg (71% of theory) of the title compound is obtained.

Sources & evidence

ORD record
ord-a153b1f35deb41a1967b371744ef52ad
Source dataset
uspto-grants-2016_03
Patent number
US09296720B2

Reaction notes

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