HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiazolidine → [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-[2-(trifluoromethyl)-4-pyridyl]pyrazol-3-yl]-thiazolidin-3-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiazolidine | HCID 10444 | — |
| Reactant | HCID 71576484 | HCID 71576484 | — |
| Reactant | 5-(3-Bromo-5-trifluoromethoxyphenyl)-1-(2-trifluoromethylpyridin-4-yl)-1H-pyrazole-3-carboxylic acid | HCID 89610054 | — |
| Product | [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-[2-(trifluoromethyl)-4-pyridyl]pyrazol-3-yl]-thiazolidin-3-yl-methanone | HCID 86574676 | — |
Reaction Steps
130 mg (0.26 mmol) of the compound of Example 47A is reacted analogously to the synthesis of the compound of Example 1 with 26 mg (0.29 mmol) of thiazolidine. 105 mg (71% of theory) of the title compound is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296720B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-a153b1f35deb41a1967b371744ef52ad |
| Source note | uspto-grants-2016_03 |