反应详情

温度

165 °C

In a 100 mL round-bottom flask were added 3-ethyl 6-methyl 2-amino-1H-indole-3,6-dicarboxylate (1.1 g, 4.19 mmol), ammonium formate (0.53 g, 8.39 mmol), and formamide (16.7 mL, 419 mmol) to give a tan suspension which was heated to 165° C. for 12 hours. The mixture was allowed to cool to room temperature and water was added. The resulting precipitate was filtered, air-dried and dried under high vacuum overnight to afford 1.1 g of the title compound. LCMS m/z 244.2 (M+H)+, retention time (on analytical HPLC)=1.51 minutes.

1. customto give a tan suspension which
2. temperatureto cool to room temperature
3. filtrationThe resulting precipitate was filtered
4. customair-dried
5. customdried under high vacuum overnight