Hydrochloric Acid → HCID 86732214, compound

Participants

Reaction Conditions

Reaction Steps

(4S,6S)-4-(5-amino-2-fluoropyridin-3-yl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (14b, 0.650 g, 2.224 mmol, as described in Example 146, method U, Step 2), hydrogen chloride, 4.0 N solution in 1,4-dioxane (1.0 mL, 28.8 mmol) and water 0.5 mL were combined in a microwave tube. The vials was sealed and heated at 100° C. for 3 h. The mixture was concentrated to dryness and carried to the next step without purification. MS m/z=291.0 [M+H]+. Calculated for C11H13F3N4O2: 290.2

Provenance & Evidence