Hydrochloric Acid → HCID 86732214, compound

HRID 930385Notes

Reaction equation

HRID 930385 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C@:10]2([CH3:21])[CH2:15][C@@H:14]([C:16]([F:19])([F:18])[F:17])[O:13][C:12]([NH2:20])=[N:11]2)[C:5]([O:8]C)=[N:6][CH:7]=1.Cl.O1CCOCC1>O>[NH2:1][C:2]1[CH:3]=[C:4]([C@:10]2([CH3:21])[CH2:15][C@@H:14]([C:16]([F:19])([F:18])[F:17])[O:13][C:12]([NH2:20])=[N:11]2)[C:5](=[O:8])[NH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86732215HCID 86732215, compound

Product 1

HCID 86732214HCID 86732214, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

(4S,6S)-4-(5-amino-2-fluoropyridin-3-yl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (14b, 0.650 g, 2.224 mmol, as described in Example 146, method U, Step 2), hydrogen chloride, 4.0 N solution in 1,4-dioxane (1.0 mL, 28.8 mmol) and water 0.5 mL were combined in a microwave tube. The vials was sealed and heated at 100° C. for 3 h. The mixture was concentrated to dryness and carried to the next step without purification. MS m/z=291.0 [M+H]+. Calculated for C11H13F3N4O2: 290.2

Workup

  1. customThe vials was sealed
  2. concentrationThe mixture was concentrated to dryness
  3. customcarried to the next step without purification

Sources & evidence

ORD record
ord-93ea9c035f51491baebf823f4847ba8e
Source dataset
uspto-grants-2016_03
Patent number
US09296734B2

Reaction notes

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