5-Chloro-3-methoxy-pyridine-2-carboxylic acid → 4-Chloro-7-methoxypyrido(3,2-d)pyrimidine

HRID 930453Notes

Reaction equation

HRID 930453 reaction equation
[Cl:1]C1C=C(OC)C(C(O)=O)=NC=1.[CH3:13][O:14][C:15]1[CH:24]=[N:23][C:22]2[C:21](=O)[N:20]=[CH:19][NH:18][C:17]=2[CH:16]=1>>[Cl:1][C:21]1[C:22]2[N:23]=[CH:24][C:15]([O:14][CH3:13])=[CH:16][C:17]=2[N:18]=[CH:19][N:20]=1

Participants

3

Reactant 2

HCID 840704685-Chloro-3-methoxy-pyridine-2-carboxylic acidHCID 178493687HCID 178493687, compound

Product 1

HCID 867159014-Chloro-7-methoxypyrido(3,2-d)pyrimidine

Procedure

Using an analogous reaction to that described for Intermediate 14, step 3, 7-methoxypyrido[3,2-d]pyrimidin-4(1H)-one was converted to the title compound. LC/MS (ESI+) m/z=196 (M+H).

Workup

  1. customan analogous reaction to

Sources & evidence

ORD record
ord-68cdb2d555de43d191cd428075329bde
Source dataset
uspto-grants-2016_03
Patent number
US09296734B2

Reaction notes

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