反应详情

温度

70 °C

In a 1-L flask, the methyl 3-methylpyrazine-2-carboxylate (step 1, 16.08 g, 106 mmol) was suspended in CHCl3 (300 mL). 3-chlorobenzoperoxoic acid (Aldrich, 24.62 g, 143 mmol) was added. The reaction mixture was heated to 70° C. for 16 h. The reaction mixture was quenched with saturated NaHCO3 (200 mL). The layers were separated, and the aqueous layer was further extracted with DCM (2×100 mL). The combined organic layers were dried over MgSO4, and the filtrate was concentrated to afford the title compound. MS m/z=169 [M+H]+. Calculated for C7H8N2O3: 168.

1. customThe reaction mixture was quenched with saturated NaHCO3 (200 mL)
2. customThe layers were separated
3. extractionthe aqueous layer was further extracted with DCM (2×100 mL)
4. dry with materialThe combined organic layers were dried over MgSO4
5. concentrationthe filtrate was concentrated