Hydrochloric Acid → 5-(6-Amino-1-benzyl-1H-benzoimidazol-2-yl)-1,3-dimethyl-1H-pyridin-2-one

Participants

Reaction Conditions

Reaction Steps

N-[3-Benzyl-2-(1,5-dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3H-benzoimidazol-5-yl]-acetamide I-9″ (3.000 g; 7.763 mmol) is suspended in 8 N HCl (74 mmol). The reaction mixture is stirred for 3 h at 100° C. The reaction is cooled to RT and then quenched slowly with sodium bicarbonate (until reaching a basic pH). The reaction is extracted with MeOH/DCM. The combined organic layer is dried over Na2SO4 and concentrated in vacuum.

Provenance & Evidence