反应详情

温度

100 °C

N-[3-Benzyl-2-(1,5-dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3H-benzoimidazol-5-yl]-acetamide I-9″ (3.000 g; 7.763 mmol) is suspended in 8 N HCl (74 mmol). The reaction mixture is stirred for 3 h at 100° C. The reaction is cooled to RT and then quenched slowly with sodium bicarbonate (until reaching a basic pH). The reaction is extracted with MeOH/DCM. The combined organic layer is dried over Na2SO4 and concentrated in vacuum.

1. temperatureThe reaction is cooled to RT
2. customquenched slowly with sodium bicarbonate (
3. extractionThe reaction is extracted with MeOH/DCM
4. dry with materialThe combined organic layer is dried over Na2SO4
5. concentrationconcentrated in vacuum