Thionyl Chloride → 1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carbonyl chloride

HRID 930523Notes

Reaction equation

HRID 930523 reaction equation
[CH3:1][N:2]1[C:7](=[O:8])[C:6]([CH3:9])=[CH:5][C:4]([C:10]([OH:12])=O)=[CH:3]1.S(Cl)([Cl:15])=O>>[CH3:1][N:2]1[C:7](=[O:8])[C:6]([CH3:9])=[CH:5][C:4]([C:10]([Cl:15])=[O:12])=[CH:3]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 218859251,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Product 1

HCID 1178895461,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carbonyl chlorideYield 100%

Conditions

Temperature
60 °C

Procedure

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid D1 (500.000 mg; 2.991 mmol) is suspended in thionyl chloride (2.000 ml; 27.536 mmol) and heated for 2 h at 60° C. The reaction mixture is concentrated under reduced pressure. And used in the next reaction without further purification (Yield: 100%).

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customAnd used in the next reaction without further purification (Yield: 100%)

Sources & evidence

ORD record
ord-2629e3e720614e108bb7b741e31a794f
Source dataset
uspto-grants-2016_03
Patent number
US09296748B2

Reaction notes

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