反应详情

A solution of 1,5-dimethyl-6-oxo-1,6-dihydro-pyridine-3-carbonyl chloride D1′ (100.000 mg; 0.598 mmol) in dry DCM (2.000 ml) is added dropwise to a solution of N2-benzyl-4-fluoro-benzene-1,2-diamine hydrochloride E-1.4 (151.180 mg; 0.598 mmol) in DCM (2.000 ml) and triethylamin (0.249 ml; 1.795 mmol). The mixture is stirred for 1 h. Precipitation occurs; the residue is filtered off and washed with DCM (2 ml). The precipitate is then dried under vacuum (Yield: 85%, 186 mg; 0.509 mmol)

1. customPrecipitation
2. filtrationthe residue is filtered off
3. washwashed with DCM (2 ml)
4. customThe precipitate is then dried under vacuum (Yield: 85%, 186 mg; 0.509 mmol)