Benzylamine → N-Benzyl-5-fluoro-2-nitroaniline

Participants

Reaction Conditions

Reaction Steps

2,4-Difluoronitrobenzene E-1.1′″ (3.448 ml; 31.429 mmol) is dissolved in dioxane (35.000 ml). DIPEA (6.601 ml; 40.857 mmol) and benzylamine (3.429 ml; 31.429 mmol) are added. The reaction mixture is stirred at 50° C. overnight. The reaction mixture is concentrated under reduced pressure. The residue crystallises after some minutes. It is triturated with diethyl ether to give the pure crystalline compound.

Provenance & Evidence