反应详情

温度

50 °C

2,4-Difluoronitrobenzene E-1.1′″ (3.448 ml; 31.429 mmol) is dissolved in dioxane (35.000 ml). DIPEA (6.601 ml; 40.857 mmol) and benzylamine (3.429 ml; 31.429 mmol) are added. The reaction mixture is stirred at 50° C. overnight. The reaction mixture is concentrated under reduced pressure. The residue crystallises after some minutes. It is triturated with diethyl ether to give the pure crystalline compound.

1. concentrationThe reaction mixture is concentrated under reduced pressure
2. customThe residue crystallises after some minutes
3. customIt is triturated with diethyl ether
4. customto give the pure crystalline compound