反应详情

温度

160 °C

Benzyl-(5-fluoro-2-nitro-phenyl)-amine E-1.1″ (2.000 g; 6.579 mmol) is dissolved in acetonitril (10.000 ml). N-Methylpiperazine (1.460 ml; 13.158 mmol) is then added. The reaction mixture is stirred for 40 min at 160° C. in a Biotage XP Sixty microwave. The reaction mixture is poured into water and extracted with 3×50 ml DCM. The combined organic layer is dried over MgSO4 and concentrated under reduced pressure. The residue is used in the next step without further purification.

1. extractionextracted with 3×50 ml DCM
2. dry with materialThe combined organic layer is dried over MgSO4
3. concentrationconcentrated under reduced pressure
4. customThe residue is used in the next step without further purification