HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 930549Generated: October 30, 2026
Tetrahydrofuran → 1-N-benzyl-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine
https://huagongshe.com/reaction/930549
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | N-benzyl-6-(4-methylpiperazin-1-yl)-3-nitropyridin-2-amine | HCID 117892066 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 1-N-benzyl-5-(4-methylpiperazin-1-yl)benzene-1,2-diamine | HCID 90161011 | — |
Reaction Steps
Benzyl-[6-(4-methyl-piperazin-1-yl)-3-nitro-pyridin-2-yl]-amine E-3.1′ (600 mg; 1.833 mmol) is dissolved in THF and palladium on carbon is added. The reaction mixture is stirred for 2.5 h at 25° C. and 4 bar hydrogen pressure. The catalyst is filtered off under celite, the filtrate is concentrated and dried under reduced pressure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09296748B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-0b6d70165bb945fe8590c26b0961a13f |
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| Source note | uspto-grants-2016_03 |
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