2-Bromo-5-methylpyridine → HCID 57950421, compound

HRID 930725Notes

Reaction equation

HRID 930725 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=1.[CH3:9][O:10][C:11]1[CH:16]=[C:15](B2OC(C)(C)C(C)(C)O2)[CH:14]=[CH:13][N:12]=1>>[CH3:9][O:10][C:11]1[CH:16]=[C:15]([C:2]2[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][N:3]=2)[CH:14]=[CH:13][N:12]=1

Participants

3

Reactant 2

HCID 5642162-Bromo-5-methylpyridineHCID 447548622-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Product 1

HCID 57950421HCID 57950421, compoundYield 42.2%

Procedure

2-Bromo-5-methylpyridine (2.93 g, 17.0 mmol) and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (3.34 g, 14.2 mmol) were reacted according to Example 31 (step a) to provide the title compound (1.2 g, 42%) as a brown solid: ESI MS m/z 201 [M+H]+.

Sources & evidence

ORD record
ord-16d55bd2842647a2b7deeecb8384462a
Source dataset
uspto-grants-2016_03
Patent number
US09296743B2

Reaction notes

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