(4-(4-Chloro-3-(trifluoromethyl)phenoxy)-3-fluorophenyl)methanol → 8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)-3-fluorobenzyl)oxy)-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 930812Notes

Reaction equation

HRID 930812 reaction equation
Cl[C:2]1[CH:14]=[C:6]2[N:7]([CH:11]3[CH2:13][CH2:12]3)[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:15])[N:3]=1.[Cl:16][C:17]1[CH:32]=[CH:31][C:20]([O:21][C:22]2[CH:27]=[CH:26][C:25]([CH2:28][OH:29])=[CH:24][C:23]=2[F:30])=[CH:19][C:18]=1[C:33]([F:36])([F:35])[F:34]>>[Cl:16][C:17]1[CH:32]=[CH:31][C:20]([O:21][C:22]2[CH:27]=[CH:26][C:25]([CH2:28][O:29][C:2]3[CH:14]=[C:6]4[N:7]([CH:11]5[CH2:13][CH2:12]5)[CH2:8][CH2:9][CH2:10][N:5]4[C:4](=[O:15])[N:3]=3)=[CH:24][C:23]=2[F:30])=[CH:19][C:18]=1[C:33]([F:36])([F:34])[F:35]

Participants

3

Reactant 2

HCID 71236627(4-(4-Chloro-3-(trifluoromethyl)phenoxy)-3-fluorophenyl)methanolHCID 903065708-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Product 1

HCID 771072328-((4-(4-chloro-3-(trifluoromethyl)phenoxy)-3-fluorobenzyl)oxy)-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and (4-(4-chloro-3-(trifluoromethyl)phenoxy)-3-fluorophenyl)methanol.

Sources & evidence

ORD record
ord-d0265738dbfb4dc7ba0e868496885d67
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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