(3-Fluoro-4-(3-fluorophenoxy)phenyl)methanol → 1-cyclopropyl-8-((3-fluoro-4-(3-fluorophenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 930816Notes

Reaction equation

HRID 930816 reaction equation
Cl[C:2]1[CH:14]=[C:6]2[N:7]([CH:11]3[CH2:13][CH2:12]3)[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:15])[N:3]=1.[F:16][C:17]1[CH:18]=[C:19]([CH2:31][OH:32])[CH:20]=[CH:21][C:22]=1[O:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=1>>[CH:11]1([N:7]2[CH2:8][CH2:9][CH2:10][N:5]3[C:4](=[O:15])[N:3]=[C:2]([O:32][CH2:31][C:19]4[CH:20]=[CH:21][C:22]([O:23][C:24]5[CH:29]=[CH:28][CH:27]=[C:26]([F:30])[CH:25]=5)=[C:17]([F:16])[CH:18]=4)[CH:14]=[C:6]23)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 28946122(3-Fluoro-4-(3-fluorophenoxy)phenyl)methanolHCID 903065708-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Product 1

HCID 771072361-cyclopropyl-8-((3-fluoro-4-(3-fluorophenoxy)benzyl)oxy)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E2 starting from 8-chloro-1-cyclopropyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one and (3-fluoro-4-(3-fluorophenoxy)phenyl) methanol.

Sources & evidence

ORD record
ord-0a2de70dcd494fd0a59363f158ccf694
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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