Pyrrolidine → 8-((3,4-difluorobenzyl)oxy)-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 930820Notes

Reaction equation

HRID 930820 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:5][O:6][C:7]1[CH:20]=[C:11]2[N:12]([CH2:16][C:17]([OH:19])=O)[CH2:13][CH2:14][CH2:15][N:10]2[C:9](=[O:21])[N:8]=1.[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:5][O:6][C:7]1[CH:20]=[C:11]2[N:12]([CH2:16][C:17](=[O:19])[N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)[CH2:13][CH2:14][CH2:15][N:10]2[C:9](=[O:21])[N:8]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 90303921HCID 90303921, compound

Product 1

HCID 771074388-((3,4-difluorobenzyl)oxy)-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E13 starting from 2-(8-((3,4-difluorobenzyl)oxy)-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidin-1-yl)acetic acid and pyrrolidine.

Sources & evidence

ORD record
ord-9a38ce0f5b124d4e99e62cb7ac7dfe10
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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