1-Methylpiperazine → 8-((3,4-difluorobenzyl)oxy)-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 930821Notes

Reaction equation

HRID 930821 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:5][O:6][C:7]1[CH:20]=[C:11]2[N:12]([CH2:16][C:17](O)=[O:18])[CH2:13][CH2:14][CH2:15][N:10]2[C:9](=[O:21])[N:8]=1.[CH3:26][N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:5][O:6][C:7]1[CH:20]=[C:11]2[N:12]([CH2:16][C:17]([N:30]3[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]3)=[O:18])[CH2:13][CH2:14][CH2:15][N:10]2[C:9](=[O:21])[N:8]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 90303921HCID 90303921, compound

Product 1

HCID 771074398-((3,4-difluorobenzyl)oxy)-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E13 starting from 2-(8-((3,4-difluorobenzyl)oxy)-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidin-1-yl)acetic acid and 1-methylpiperazine.

Sources & evidence

ORD record
ord-8bfc70fff0b048f784dbc242681ed329
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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