4,4-Difluoropiperidine → 8-((3,4-difluorobenzyl)oxy)-1-(2-(4,4-difluoropiperidin-1-yl)-2-oxoethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

HRID 930822Notes

Reaction equation

HRID 930822 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:5][O:6][C:7]1[CH:20]=[C:11]2[N:12]([CH2:16][C:17]([OH:19])=O)[CH2:13][CH2:14][CH2:15][N:10]2[C:9](=[O:21])[N:8]=1.[F:26][C:27]1([F:33])[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:5][O:6][C:7]1[CH:20]=[C:11]2[N:12]([CH2:16][C:17]([N:30]3[CH2:31][CH2:32][C:27]([F:33])([F:26])[CH2:28][CH2:29]3)=[O:19])[CH2:13][CH2:14][CH2:15][N:10]2[C:9](=[O:21])[N:8]=1

Participants

3

Reactant 2

HCID 27583524,4-DifluoropiperidineHCID 90303921HCID 90303921, compound

Product 1

HCID 768532338-((3,4-difluorobenzyl)oxy)-1-(2-(4,4-difluoropiperidin-1-yl)-2-oxoethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E13 starting from 2-(8-((3,4-difluorobenzyl)oxy)-6-oxo-2,3,4,6-tetrahydro-1H-pyrimido[1,6-a]pyrimidin-1-yl)acetic acid and 4,4-difluoropiperidine.

Sources & evidence

ORD record
ord-b9bc6cf0208b400386c90a312e35dc98
Source dataset
uspto-grants-2016_03
Patent number
US09296755B2

Reaction notes

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