Thionyl Chloride → HCID 89657740, compound

HRID 930924Notes

Reaction equation

HRID 930924 reaction equation
[F:1][C:2]1[CH:31]=[C:30]([F:32])[CH:29]=[CH:28][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([CH3:14])(=[O:13])=[O:12])=[CH:7][C:6]=1[C:15]1[C:16]2[CH:25]=[C:24]([CH2:26]O)[NH:23][C:17]=2[C:18](=[O:22])[N:19]([CH3:21])[CH:20]=1.S(Cl)([Cl:35])=O>>[Cl:35][CH2:26][C:24]1[NH:23][C:17]2[C:18](=[O:22])[N:19]([CH3:21])[CH:20]=[C:15]([C:6]3[CH:7]=[C:8]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:9]=[CH:10][C:5]=3[O:4][C:3]3[CH:28]=[CH:29][C:30]([F:32])=[CH:31][C:2]=3[F:1])[C:16]=2[CH:25]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 89656277HCID 89656277, compound

Product 1

HCID 89657740HCID 89657740, compound

Procedure

A mixture of Example 276 (0.50 g, 1.09 mmol) and thionyl chloride (5.0 mL, 69 mmol) was heated under reflux for 2 hours. The solvent was removed under reduced pressure and the residue was dried under vacuo for 1 hour to provide the title compound.

Workup

  1. temperatureunder reflux for 2 hours
  2. customThe solvent was removed under reduced pressure
  3. customthe residue was dried under vacuo for 1 hour

Sources & evidence

ORD record
ord-4e5f5dd0a68349f18d6d8fe6efe45801
Source dataset
uspto-grants-2016_03
Patent number
US09296741B2

Reaction notes

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