2-Hydroxyisobutyric acid → HCID 90014556, compound

HRID 930970Notes

Reaction equation

HRID 930970 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][C:6]2[C:9]3[C:14]([NH:15][C:16]4[CH:25]=[CH:24][C:19]5[NH:20][C:21](=[O:23])[S:22][C:18]=5[CH:17]=4)=[N:13][CH:12]=[N:11][C:10]=3[S:26][C:5]=2[CH2:4]1.[OH:27][C:28]([CH3:33])([CH3:32])[C:29](O)=[O:30]>>[OH:27][C:28]([CH3:33])([CH3:32])[C:29]([NH:1][CH2:2][CH:3]1[CH2:8][CH2:7][C:6]2[C:9]3[C:14]([NH:15][C:16]4[CH:25]=[CH:24][C:19]5[NH:20][C:21](=[O:23])[S:22][C:18]=5[CH:17]=4)=[N:13][CH:12]=[N:11][C:10]=3[S:26][C:5]=2[CH2:4]1)=[O:30]

Participants

3

Reactant 2

HCID 116712-Hydroxyisobutyric acidHCID 90014477HCID 90014477, compound

Product 1

HCID 90014556HCID 90014556, compound

Procedure

10 mg (130 μmol) (RS)-6-{[7-(aminomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]amino}-1,3-benzothiazol-2(3H)-one (prepared according to example 20) were transformed in analogy to example 23 using 2-hydroxy-2-methylpropanoic acid to give after working up and purification 23.8 mg (38%) of the title compound.

Workup

  1. customto give
  2. custompurification 23.8 mg (38%) of the title compound

Sources & evidence

ORD record
ord-f048de1fa26c435599931b6d373210a7
Source dataset
uspto-grants-2016_03
Patent number
US09296757B2

Reaction notes

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