2-Propanesulfonyl chloride → HCID 90014761, compound

HRID 930973Notes

Reaction equation

HRID 930973 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][C:6]2[C:9]3[C:14]([NH:15][C:16]4[CH:25]=[CH:24][C:19]5[NH:20][C:21](=[O:23])[S:22][C:18]=5[CH:17]=4)=[N:13][CH:12]=[N:11][C:10]=3[S:26][C:5]=2[CH2:4]1.[CH3:27][CH:28]([S:30](Cl)(=[O:32])=[O:31])[CH3:29]>>[O:23]=[C:21]1[NH:20][C:19]2[CH:24]=[CH:25][C:16]([NH:15][C:14]3[C:9]4[C:6]5[CH2:7][CH2:8][CH:3]([CH2:2][NH:1][S:30]([CH:28]([CH3:29])[CH3:27])(=[O:32])=[O:31])[CH2:4][C:5]=5[S:26][C:10]=4[N:11]=[CH:12][N:13]=3)=[CH:17][C:18]=2[S:22]1

Participants

3

Reactant 2

HCID 824082-Propanesulfonyl chlorideHCID 90014477HCID 90014477, compound

Product 1

HCID 90014761HCID 90014761, compound

Procedure

75 mg (196 μmol) (RS)-6-{[7-(aminomethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl]amino}-1,3-benzothiazol-2(3H)-one (prepared according to example 20), were transformed in analogy to example 21 using propane-2-sulfonyl chloride to give after working up and purification 5.7 mg (6%) of the title compound.

Workup

  1. customto give
  2. custompurification 5.7 mg (6%) of the title compound

Sources & evidence

ORD record
ord-7b8ce7e271e5454faa7468ddf1140471
Source dataset
uspto-grants-2016_03
Patent number
US09296757B2

Reaction notes

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