1-Methylpiperazine → HCID 90014997, compound

HRID 930974Notes

Reaction equation

HRID 930974 reaction equation
[O:1]=[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([NH:11][C:12]3[C:13]4[C:20]5[CH2:21][CH2:22][CH:23]([C:25]([OH:27])=O)[CH2:24][C:19]=5[S:18][C:14]=4[N:15]=[CH:16][N:17]=3)=[CH:10][C:4]=2[S:3]1.[CH3:28][N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1>>[CH3:28][N:29]1[CH2:34][CH2:33][N:32]([C:25]([CH:23]2[CH2:22][CH2:21][C:20]3[C:13]4[C:12]([NH:11][C:9]5[CH:8]=[CH:7][C:5]6[NH:6][C:2](=[O:1])[S:3][C:4]=6[CH:10]=5)=[N:17][CH:16]=[N:15][C:14]=4[S:18][C:19]=3[CH2:24]2)=[O:27])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 90014843HCID 90014843, compound

Product 1

HCID 90014997HCID 90014997, compound

Procedure

76.4 mg (192 μmol) (RS)-4-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to example 2) were transformed in analogy to example 3 using 1-methylpiperazine to give after working up and purification 66.5 mg (69%) of the title compound.

Workup

  1. customto give
  2. custompurification 66.5 mg (69%) of the title compound

Sources & evidence

ORD record
ord-3330da0ee9514fe89fa01273c925e658
Source dataset
uspto-grants-2016_03
Patent number
US09296757B2

Reaction notes

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