反应详情

To a suspension of potassium tert-butoxide (5.2 g) in IPE (50 mL) were added ethyl 2-chloroacetate (5.6 g) and ethyl formate (3.4 g) under ice-cooling, and the mixture was stirred overnight at room temperature. The precipitate was collected by filtration, and dried to give the title compound (5.8 g). 1H NMR (300 MHz, DMSO-d6) δ 1.11 (3H, t, J=7.2 Hz), 3.92 (2H, q, J=7.2 Hz), 8.95 (1H, brs).

1. temperaturecooling
2. filtrationThe precipitate was collected by filtration
3. customdried