4-(Trifluoromethyl)-1H-pyrazole → OC(=O)C1(CC1)n1cc(cn1)C(F)(F)F

HRID 931068Notes

Reaction equation

HRID 931068 reaction equation
F[C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10]([OH:12])=[O:11])[CH2:9][CH2:8]2)[CH:6]=1.[F:13][C:14]([F:21])([F:20])C1C=NNC=1>>[F:13][C:14]([F:21])([F:20])[C:2]1[CH:3]=[N:4][N:5]([C:7]2([C:10]([OH:12])=[O:11])[CH2:9][CH2:8]2)[CH:6]=1

Participants

3

Reactant 2

HCID 127777954-(Trifluoromethyl)-1H-pyrazoleHCID 898533361-(4-Fluoro-1H-pyrazol-1-yl)cyclopropanecarboxylic acid

Product 1

HCID 117966508OC(=O)C1(CC1)n1cc(cn1)C(F)(F)F

Procedure

The title compound was prepared by a method analogous to Intermediate 4 but using 4-(trifluoromethyl)-1H-pyrazole in Step 1. 1H NMR (400 MHz, CDCl3) δ 1.60-1.79 (m, 2H), 1.83-1.95 (m, 2H), 7.75 (s, 1H), 7.78-7.89 (m, 1H), 11.82 (br s, 1H).

Sources & evidence

ORD record
ord-8d5d6e66b24f41fe9987fc46b484e9b4
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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