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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 931068Generated: October 27, 2026

4-(Trifluoromethyl)-1H-pyrazole → OC(=O)C1(CC1)n1cc(cn1)C(F)(F)F

https://huagongshe.com/reaction/931068

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)-1H-pyrazoleHCID 12777795—
Reactant1-(4-Fluoro-1H-pyrazol-1-yl)cyclopropanecarboxylic acidHCID 89853336—
ProductOC(=O)C1(CC1)n1cc(cn1)C(F)(F)FHCID 117966508—

Reaction Steps

The title compound was prepared by a method analogous to Intermediate 4 but using 4-(trifluoromethyl)-1H-pyrazole in Step 1. 1H NMR (400 MHz, CDCl3) δ 1.60-1.79 (m, 2H), 1.83-1.95 (m, 2H), 7.75 (s, 1H), 7.78-7.89 (m, 1H), 11.82 (br s, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09296745B2
Source datasetuspto-grants-2016_03
ORD IDord-8d5d6e66b24f41fe9987fc46b484e9b4
Source noteuspto-grants-2016_03