反应详情

Sodium ethoxide (140 mg, 2.06 mmol) was added to a solution of 6-cyclopropylpyrazine-2-carbonitrile (150 mg, 1.03 mmol) in ethanol (6 mL) at room temperature. The reaction mixture was stirred at room temperature for 1 h. The solvent was removed under reduced pressure. The residue was partitioned between water and ethyl acetate. The organics were dried over sodium sulfate and concentrated under reduced pressure to afford the title compound (250 mg). MS (ES+) (M+H) 192.1012

1. customThe solvent was removed under reduced pressure
2. customThe residue was partitioned between water and ethyl acetate
3. dry with materialThe organics were dried over sodium sulfate
4. concentrationconcentrated under reduced pressure