Hydrochloric Acid → HCID 117966376, compound

Participants

Reaction Steps

To a solution of (R)-tert-butyl 3-(dimethylcarbamoyl)piperidine-1-carboxylate (9 g, 35.15 mmol) in methanol (20 mL) at 0° C. was added hydrogen chloride in methanol (50 mL). The reaction mixture was stirred at room temperature for 2 h. The solvent was evaporated in vacuo to afford (R)—N,N-dimethylpiperidine-3-carboxamide hydrochloride (7 g, 90%). MS (ES+APCI) [(M-2HCl)+H] 157.1; LCMS retention time: 6.36 min (Method F1).

Provenance & Evidence