Hydrochloric Acid → HCID 117966376, compound

HRID 931121Notes

Reaction equation

HRID 931121 reaction equation
[CH3:1][N:2]([CH3:18])[C:3]([C@@H:5]1[CH2:10][CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:19]>CO>[ClH:19].[CH3:1][N:2]([CH3:18])[C:3]([C@@H:5]1[CH2:10][CH2:9][CH2:8][NH:7][CH2:6]1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 28167727HCID 28167727, compound

Product 1

HCID 117966376HCID 117966376, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of (R)-tert-butyl 3-(dimethylcarbamoyl)piperidine-1-carboxylate (9 g, 35.15 mmol) in methanol (20 mL) at 0° C. was added hydrogen chloride in methanol (50 mL). The reaction mixture was stirred at room temperature for 2 h. The solvent was evaporated in vacuo to afford (R)—N,N-dimethylpiperidine-3-carboxamide hydrochloride (7 g, 90%). MS (ES+APCI) [(M-2HCl)+H] 157.1; LCMS retention time: 6.36 min (Method F1).

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-d80a7d1d99814f7997951f41fdaeea4c
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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