Acetonitrile → HCID 117966273, compound

HRID 931123Notes

Reaction equation

HRID 931123 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([N:16]([CH3:18])[CH3:17])=[O:15])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20].N1C[CH2:26][O:25][CH2:24]C1.C(#N)C>Cl.CCOCC>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][CH2:11][C@@H:10]([C:14]([N:16]3[CH2:18][CH2:26][O:25][CH2:24][CH2:17]3)=[O:15])[CH2:9]2)[CH:5]=[CH:4][C:3]=1[N+:19]([O-:21])=[O:20]

Participants

6

Reactant 3

HCID 6342AcetonitrileHCID 8083MorpholineHCID 117966493(R)-1-(6-amino-5-nitropyridin-2-yl)-N,N-dimethylpiperidine-3-carboxamide

Product 1

HCID 117966273HCID 117966273, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent2×

Procedure

The title compound was prepared using procedures analogous to the ones used for Intermediate 39, but using morpholine for Step 1, a saturated solution of hydrogen chloride in ether, and diethyl ether as a solvent for Step 2 and acetonitrile for Step 3. MS (ES+APCI) (M+H) 336.1; LCMS retention time: 4.033 min (Method I).

Sources & evidence

ORD record
ord-b04003c05bfd4dd382530bc4f9f82c47
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

Loading…