反应详情

To a solution of (R)-tert-butyl 3-(ethyl(methyl)carbamoyl)piperidine-1-carboxylate (1 g, 3.7 mmol) in diethyl ether (10 mL) at 0° C. was added ethereal hydrogen chloride (15 mL). The reaction mixture was warmed to room temperature and was stirred at that temperature for 30 min. The solvent was distilled and the resulting residue was washed with diethyl ether to afford (R)—N-ethyl-N-methylpiperidine-3-carboxamide (1 g). MS (ES+) (M+H) 171.23; LCMS retention time 2.38 min (Method M1).

1. distillationThe solvent was distilled
2. washthe resulting residue was washed with diethyl ether