Hydrochloric Acid → HCID 117966332, compound

HRID 931146Notes

Reaction equation

HRID 931146 reaction equation
[ClH:1].[CH3:2][S:3][C:4]1[CH:5]=[N:6][N:7]([C:9]2([C:12]#[N:13])[CH2:11][CH2:10]2)[CH:8]=1.[CH2:14]([OH:16])[CH3:15]>>[ClH:1].[CH3:2][S:3][C:4]1[CH:5]=[N:6][N:7]([C:9]2([C:12](=[NH:13])[O:16][CH2:14][CH3:15])[CH2:11][CH2:10]2)[CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702Ethanol2×HCID 117966431HCID 117966431, compound

Product 1

HCID 117966332HCID 117966332, compound

Procedure

To a saturated solution of hydrogen chloride in ethanol (3.5 mL) at 0° C. was added a solution of 1-(4-(methylthio)-1H-pyrazol-1-yl)cyclopropanecarbonitrile (125 mg, 0.697 mmol) in ethanol (0.5 mL). The reaction mixture was stirred at room temperature for 1.5 h. The solvent was removed under a stream of nitrogen to afford the title compound (210 mg). The material was used without further purification.

Workup

  1. customThe solvent was removed under a stream of nitrogen

Sources & evidence

ORD record
ord-05409a69a78e49f08559e0e6944c45cc
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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