2-Iodoxybenzoic acid → HCID 87628351, compound

HRID 931165Notes

Reaction equation

HRID 931165 reaction equation
[N:1]1([C:6]2([CH2:9][OH:10])[CH2:8][CH2:7]2)[CH:5]=[CH:4][N:3]=[CH:2]1.I(C1C=CC=CC=1C(O)=O)(=O)=O>C(OCC)(=O)C>[N:1]1([C:6]2([CH:9]=[O:10])[CH2:8][CH2:7]2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 1087942-Iodoxybenzoic acidHCID 77230224858036-12-1

Product 1

HCID 87628351HCID 87628351, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (1-(1H-imidazol-1-yl)cyclopropyl)methanol (42.39 mg, 0.307 mmol) in anhydrous ethyl acetate (10 mL) was added 2-iodoxybenzoic acid (IBX) (129 mg, 0.461 mmol). The reaction mixture was heated at reflux for 2 h. The mixture was filtered and the filtrate was concentrated to afford the title compound which was used for the next step without further purification.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2 h
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-be8b6cd9b8784362b34be9befe111a21
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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