HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 931182Generated: November 1, 2026
Hydrochloric Acid → (R)-piperidin-3-yl(pyrrolidin-1-yl)methanone
https://huagongshe.com/reaction/931182
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | (R)-tert-butyl 3-(pyrrolidine-1-carbonyl)piperidine-1-carboxylate | HCID 28167609 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-piperidin-3-yl(pyrrolidin-1-yl)methanone | HCID 7169819 | — |
Reaction Steps
Into a flask containing (R)-tert-butyl 3-(pyrrolidine-1-carbonyl)piperidine-1-carboxylate was added dichloromethane (24 mL) followed by a solution of hydrogen chloride in 1,4-dioxane (4M, 8 mL). The reaction mixture was stirred at 30° C. for 2 h. The solvent was evaporated under reduced pressure to afford (R)-piperidin-3-yl(pyrrolidin-1-yl)methanone which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09296745B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-b8f3eaca78464e05b10bf14f0562d2af |
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| Source note | uspto-grants-2016_03 |
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