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HRID931189

反应详情

EQUATION

反应方程式

HRID 931189 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：O=S([O-])S(=O)[O-].[Na+].[Na+]
HCID24489

Dithionous acid, disodium salt

Na2O4S2

结构：O=Cc1cccc(OC(F)F)c1
HCID2736985

3-(Difluoromethoxy)benzaldehyde

C8H6F2O2

结构：CN(C)C(=O)[C@@H]1CCCN(c2ccc([N+](=O)[O-])c(N)n2)C1
HCID117966493

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C(=O)[C@@H]1CCCN(c2ccc3nc(-c4cccc(OC(F)F)c4)[nH]c3n2)C1
HCID178484578

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

CONDITIONS

反应条件

温度
110 °C

PROCEDURE

实验过程

Into a 4 mL vial was added (R)-1-(6-amino-5-nitropyridin-2-yl)-N,N-dimethylpiperidine-3-carboxamide (500 μL, 0.3M) dissolved in N,N-dimethylformamide followed by 3-(difluoromethoxy)benzaldehyde (950 μL, 0.158M) dissolved in N,N-dimethylformamide. Water (50 μL) was added followed by sodium hydrosulfite (574 μmol) under a nitrogen atmosphere. The vial was capped and shaken at 110° C. for 18 h. The solvent was removed by Speedvac and the residue was purified by HPLC to afford the title compound. MS (API-ES+) (M+H) 416.2; HPLC retention time 1.392 min (Method E).

WORKUP

后处理

  1. customThe vial was capped
  2. customThe solvent was removed by Speedvac
  3. customthe residue was purified by HPLC